Chelsea will play holders Paris St-Germain in the Champions League round of 16 while Manchester City will face Real Madrid in the knockout stages for a fifth straight season.
Although six Premier League clubs have qualified for the last 16 there will be no all-English ties, with leaders Arsenal to face Bayer Leverkusen.
Newcastle United will meet Barcelona, Liverpool take on Galatasaray and Tottenham have been drawn against Atletico Madrid.
The first legs will be played on 10 and 11 March, with the second legs to take place on 17 and 18 March.
Newcastle are at home for their first leg with Barca, while their Premier League rivals are all at home for their second leg having qualified for the last 16 automatically.
Chelsea’s tie with PSG is a rematch of last year’s Fifa Club World Cup final, when the Blues beat PSG 3-0 in New Jersey.
“It’ll be tough but it holds no fear for us,” said Chelsea’s director of football David Barnard.
Man City, Newcastle and Liverpool all met their opponents during the league phase of this season’s competition.
The route to the final is already known and if Newcastle and Tottenham both progress, they will meet in the quarter-finals, as will Chelsea and Liverpool in the other half of the draw.
The final will be played at the Puskas Arena in Budapest, Hungary, on Saturday, 30 May.
Draw made Friday for the Champions League knockout bracket:
Round of 16
First leg
March 10-11
Paris Saint-Germain vs. Chelsea
Galatasaray vs. Liverpool
Real Madrid vs. Manchester City
Atalanta vs. Bayern Munich
Newcastle vs. Barcelona
Atletico Madrid vs. Tottenham
Bodø/Glimt vs. Sporting Lisbon
Bayer Leverkusen vs. Arsenal
Second leg
March 17-18
Chelsea vs. Paris Saint-Germain
Liverpool vs. Galatasaray
Manchester City vs. Real Madrid
Bayern Munich vs. Atalanta
Barcelona vs. Newcastle
Tottenham vs. Atletico Madrid
Sporting Lisbon vs. Bodø/Glimt
Arsenal vs. Bayer Leverkusen
___
Quarterfinals
First leg
April 7-8
Paris Saint-Germain or Chelsea vs. Galatasaray or Liverpool
Real Madrid or Manchester City vs. Atalanta or Bayern Munich
Newcastle or Barcelona vs. Atletico Madrid or Tottenham
Bodø/Glimt or Sporting Lisbon vs. Bayer Leverkusen or Arsenal
Second leg
April 14-15
Galatasaray or Liverpool vs. Paris Saint-Germain or Chelsea
Atalanta or Bayern Munich vs. Real Madrid or Manchester City
Atletico Madrid or Tottenham vs. Newcastle or Barcelona
Bayer Leverkusen or Arsenal vs. Bodø/Glimt or Sporting Lisbon
