The first Manchester derby of the season arrives at the Etihad on Sunday with a sense of unease hanging over both sides.

For Manchester City and Manchester United, a fixture usually rich in rivalry and spectacle has acquired an edge of desperation, despite the campaign being barely underway.

City find themselves in the unfamiliar territory of 16th place after three games, suffering back-to-back defeats against Tottenham Hotspur and Brighton following an opening-day victory at Wolves.

For Pep Guardiola, who has built a reputation on relentless consistency, the prospect of a third consecutive loss against the club’s fiercest rivals would represent more than a blip. It could set the tone for a season already threatening to unravel.

United, under Ruben Amorim, sit five places above in 11th but are hardly more convincing. Their Europa League final defeat to Spurs last spring capped a dismal campaign that saw them finish 15th in the league.

Already out of the Carabao Cup to League Two Grimsby Town, they scraped past Burnley with a late Bruno Fernandes penalty before the international break. Amorim has already been forced to fend off speculation about his future and knows a defeat at the Etihad would amplify the pressure.

The stakes are heightened by timing. United have a week to prepare before facing Chelsea at Old Trafford, while City must quickly switch focus to Napoli in the Champions League.

A win for Amorim’s side would pull them level on points with Everton and Sunderland in the European places. For Guardiola, victory would lift his team into the top half of the table and ease growing concerns.

Derbies always carry weight, but Sunday’s feels unusually pivotal. With Liverpool and Arsenal setting the early pace, neither side can afford to stumble. It is rare for a September clash to feel like a must-win, yet this one does.