New Partnership To Cut Down Cost Of TB Drugs

Children and pregnant women with tuberculosis will now access patient-friendly treatment at a reduced cost.

This is after various partners announced plans to lower the price of rifapentine (RPT)-based treatments to prevent tuberculosis in low- and middle-income countries including Kenya.

Rifapentine is used in combination with other medicines to treat active or inactive (latent) tuberculosis.

The move by Unitaid, Aurum Institute, the Clinton Health Access Initiative (Chai) and MedAccess under the IMPAACT4TB project will also see Kenya benefit from Sh2.3 billion additional funding by Unitaid.

The additional funding will help identify the correct dosing and drug-to-drug interactions when children and pregnant women living with HIV take three months of weekly isoniazid and rifapentineor 3HP combined with dolutegravir (DTG) based Anti-Retroviral Therapy.

The funding awarded to the Aurum Institute will focus on the evidence required to ensure that children and pregnant women, including those living with HIV and household contacts have access to the latest TB prevention regimens.  

Alongside evidence generation, the project will invest in ensuring countries are aware of the need for medicines for children for TB prevention that are easier to swallow and with the appropriate dose.

Currently, 3HP tablets need to be swallowed whole, which is difficult for some children and needs to be broken into pieces to dose children appropriately, limiting access to TB prevention for children.

Once new formulations are ready, governments will, in turn, need to be ready to introduce them.  

“In recent years, we have come a long way towards improving access, at an affordable cost, to tuberculosis-prevention treatments that are shorter and easier to take, but supply has remained a constraint,” head of WHO Global Tuberculosis Programme Matteo Zignol said.

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“This announcement will help us prevent TB among more people by ensuring that there is enough supply to meet the needs of eligible countries. Ultimately, preventing TB is critical to our ability to finally end this deadly disease.”

Under the initiative, 3HP, a three-month, once-weekly oral treatment for the treatment of latent TB infection will now be available at a ceiling price of $14.25(Sh1,500).

The cost was previously as high as $333(Sh36,000).

On the other hand, Rifapentine 300 mg single tablets, used in 3HP and 1HP (a one-month, once-daily oral treatment) will be available for $33.90(Sh3,700) per 100 tablets.