Argentina, eighth in Fifa’s world rankings, have lost four Copa America finals since they last won the competition in 1993.
However, they have the chance to draw level with Uruguay on 15 wins.
Paris St-Germain winger Angel di Maria, a bright spark when he came on in the semi-final against Colombia, has mostly started on the bench along with new Barcelona signing Sergio Aguero.
Despite winning the 2019 edition, Brazil (with nine) are third in terms of Copa America triumphs
They left the likes of Liverpool forward Roberto Firmino and Real Madrid’s Vinicius Junior on the bench for their semi-final, while Manchester United’s Fred has been preferred to Liverpool’s Fabinho in midfield.
“Brazil versus Argentina is much more than a simple game of football,” added Marquinhos. “These jerseys make the world stand still to watch their games.”
Brazil’s Neymar, a former team-mate of Messi’s at Barca, is also looking to seal a first major success with his country in the first Argentina-Brazil Copa America final since 2007.
“We’re going to play a final against our eternal rivals, the lifelong ones, the two most powerful national teams in South America and we hope it will be a great match,” said Argentina boss Lionel Scaloni.
Messi, 34, has won 10 La Liga titles and four Champions Leagues during a trophy-laden career at Barcelona.
But the six-time Ballon d’Or winner’s only success with the senior Argentina team is at the 2008 Olympics in China.
“We’ll try to stop him achieving this objective,” said Brazil defender Marquinhos
